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Research Highlights

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Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Admixture of divergent genomes facilitates hybridization across species in the family Brassicaceae

Admixture of divergent genomes facilitates hybridization across species in the family Brassicaceae

Prof. Jin Hoe Huh

Hybridization and polyploidization are pivotal to plant evolution. Genetic crosses between distantly related species are rare in nature due to reproductive barriers but how such hurdles can be overcome is largely unknown.

Complex regulatory networks of virulence factors in Vibrio vulnificus

Complex regulatory networks of virulence factors in Vibrio vulnificus

Prof. Sang Ho Choi

Vibrio vulnificus produces various virulence factors that enhance its fitness in changing environments as well as host cell-damaging activities and inflammatory responses during infection.

CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation

CXCL5 inhibits excessive oxidative stress by regulating white adipocyte differentiation

Prof. Je-Yoel Cho

Chemokines have been well-documented as a major factor in immune cell migration and the regulation of immune responses.

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

Prof. Hyunsook Lee & Prof. Seong Keun Kim

BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis.

Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation

Digital selective transformation and patterning of highly conductive hydrogel bioelectronics by laser-induced phase separation

Prof. Seung Hwan Ko

The patterning of poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) hydrogels with excellent electrical property and spatial resolution is a challenge for bioelectronic applications.

Multi-omics-based autophagy-related untypical subtypes in patients with cerebral amyloid pathology

Multi-omics-based autophagy-related untypical subtypes in patients with cerebral amyloid pathology

Prof. Inhee Mook

Recent multi-omics analyses paved the way for a comprehensive understanding of pathological processes. However, only few studies have explored Alzheimer’s disease (AD) despite the possibility of biological subtypes within these patients. For this study, unsupervised classification of four datasets (genetics, miRNA transcriptomics, proteomics, and blood-based biomarkers) using Multi-Omics Factor Analysis+ (MOFA+),

The size of the land carbon sink in China

The size of the land carbon sink in China

Prof. Sujong Jeong

A substantial part of China’s anthropogenic emissions has been offset by its land carbon sink, which represents an important element in achieving carbon neutrality by 2060.

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Adipocyte HIF2α functions as a thermostat via PKA Cα regulation in beige adipocytes

Prof. Jae Bum Kim

Thermogenic adipocytes generate heat to maintain body temperature against hypothermia in response to cold. Although tight regulation of thermogenesis is required to prevent energy sources depletion, the molecular details that tune thermogenesis are not thoroughly understood.

DeepHisCoM: Deep learning pathway analysis using hierarchical structural component models

DeepHisCoM: Deep learning pathway analysis using hierarchical structural component models

Prof. Taesung Park

Many statistical methods for pathway analysis have been used to identify pathways associated with the disease along with biological factors such as genes and proteins.

Evolutionary balance between foldability and functionality of a glucose transporter

Evolutionary balance between foldability and functionality of a glucose transporter

Prof. Tae-Young Yoon

Professor Tae-Young Yoon's team from the School of Biological Sciences announced that they have revealed the folding mechanism of glucose transporter, a complex membrane protein, for the first time using magnetic tweezers.

Exploiting the full advantages of colloidal perovskite nanocrystals for large-area efficient light-emitting diodes

Exploiting the full advantages of colloidal perovskite nanocrystals for large-area efficient light-emitting diodes

Prof. Tae-Woo Lee

Professor Tae-Woo Lee's team in the Department of Material Engineering announced that they have developed the world's most effective large-scale light-emitting diodes by using metal halide perovskites, which is a promising material for lighting devices.

Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches

Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches

Prof. Sunghoon Kwon & Prof. Wonshik Ha

The joint research team led by Professor Sunghoon Kwon from the Department of Electrical and Computer Engineering and Professor Wonshik Han from the College of Medicine announced that they have developed a platform for discovering targets for new chemotherapy drugs by using technology used for analyzing cancer RNA editome.