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Research Highlights

Research Highlights /

Research Highlights

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Temporally Distinct 3D Multi-Omic Dynamics in the Developing Human Brain

Prof. Dong-Sung Lee

Professor Dongsung Lee from the College of Medicine at SNU, in collaboration with researchers at UCLA and UCSF, has published a paper in Nature, being the first in the world to study epigenomic changes, including the three-dimensional genome structure and DNA methylation, during human brain development from the fetal stage to adulthood at the single-cell level, using the single-nucleus methyl-3C technology they developed.

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Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Genomic overview of INA-induced NPR1 targeting and transcriptional cascades in Arabidopsis

Prof. Yoo-Sun Noh

The phytohormone salicylic acid (SA) triggers transcriptional reprogramming that leads to SA-induced immunity in plants. NPR1 is an SA receptor and master transcriptional regulator in SA-triggered transcriptional reprogramming.

Seoul National University

Identification of specific neutralizing antibodies for highly pathogenic avian influenza H5 2.3.4.4b clades to facilitate vaccine design and therapeutics

Prof. Seon Ju Yeo

The highly pathogenic avian influenza H5 2.3.4.4 and 2.3.2.1c subclades have distinct antigenic properties and are responsible for the majority of human infections.

Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer

Comprehensive characterization of early-programmed tumor microenvironment by tumor-associated macrophages reveals galectin-1 as an immune modulatory target in breast cancer

Prof. Seung Hyeok Seok

In recent years, there has been considerable interest in the therapeutic targeting of tumor-associated macrophages (TAMs) to modulate the tumor microenvironment (TME), resulting in antitumoral phenotypes.

Evaluation of future flood probability in agricultural reservoir watersheds using an integrated flood simulation system

Evaluation of future flood probability in agricultural reservoir watersheds using an integrated flood simulation system

Prof. Moon Seong Kang

Prof. Moon Seong Kang and his research team have developed an evaluation method for future flood probability, addressing an agricultural reservoir watershed and the hydraulic structures within.

Variants in the WDR44 WD40-Repeat Domain Cause a Spectrum of Ciliopathy by Impairing Ciliogenesis Initiation

Variants in the WDR44 WD40-Repeat Domain Cause a Spectrum of Ciliopathy by Impairing Ciliogenesis Initiation

Prof. Sung-Gyoo Park and Jong-Hee Chae

Professor Sung-Gyoo Park's research team from the College of Pharmacy at SNU has discovered WDR44 variants that induce human ciliopathy through international collaborative work with researchers from 8 nations.

Seoul National University

Chromosome-level genome assembly of chub mackerel (Scomber japonicus) from the Indo-Pacific Ocean

Prof. Heebal Kim

Chub mackerels (Scomber japonicus) are a migratory marine fish widely distributed in the Indo-Pacific Ocean.

Identification of breeding habitats and <i>kdr</i> mutations in <i>Anopheles</i> spp. in South Korea

Identification of breeding habitats and kdr mutations in Anopheles spp. in South Korea

Prof. Seon-Ju Yeo

Malaria is still endemic in South Korea. However, limited information is available on the current Anopheles breeding sites and the occurrence of insecticide resistance-associated genetic mutations and their distribution needed to control the malaria vector efficiently.

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Prof. Jae Bum Kim

Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.

Impact of chlorite dehydration on intermediate-depth earthquakes in subducting slabs

Impact of chlorite dehydration on intermediate-depth earthquakes in subducting slabs

Prof. Haemyeong Jung

Intermediate-depth earthquakes are common in the double seismic structures of many subduction zones under high pressures (~1–4 GPa).

Vortex nanolaser based on a photonic disclination cavity

Vortex nanolaser based on a photonic disclination cavity

Prof. Hong-Gyu Park

Optical vector vortex beams provide additional degrees of freedom for spatially distinguishable channels in data transmission.

Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family

Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family

Prof. Hee-Jung Choi

Structural and mechanistic studies on human odorant receptors (ORs), key in olfactory signaling, are challenging because of their low surface expression in heterologous cells.

Inference of admixture origins in indigenous African cattle

Inference of admixture origins in indigenous African cattle

Prof. Heebal Kim and Choongwon Jeong

Present-day African cattle retain a unique genetic profile composed of a mixture of the Bos taurus and B. indicus populations introduced into the continent at different time periods.